Ubiquitously available personal space travel
Improvements in wealthy and institutional space travel (EG NASA; SpaceX), though exciting, will not change the human condition on earth significantly. We need to each be able to play a powerful role in forging our future engagement with the environment.
Cure for aging
Cancer and HIV are distractions from this universally threatening terminal ailment, the cure for which will also change the practice of every other medical specialty.
Framework for global mutual support
Insurance is broken. Government is broken. There are no good examples of democracy being practiced at the scale at which it needs to have its impact for it to be a significant system in our lives. We each need to know that we will be able to depend on our fellows for help with risks inherent to life itself which are bigger than any individual can handle on their own.
Education that works, support for families from outside the family
Children are not taught what they need to know to get through childhood. They are taught the presidents of the united states before they know what is happening to them now, and what will happen in the future. Your kids have to live in the same world as your neighbor's kids. Why don't your families support each other? The way "we" raise kids, or rather, don't, is a topic too deep to scratch the surface of the tip of the iceberg here...
Pragmatic, operative, information channels
What do you need to know now? Whoever in the world knows it, they should be able to tell you. Now. This drives everything else. AI is a distraction from human intelligence. What we do with our lives should be to help each other. That's what economics is really for.